ʻO ka maʻi maʻi maʻi maʻi maʻi maʻi (CKD) pinepine ka hyperphosphatemia, a hiki i ka hyperphosphatemia lōʻihi ke alakaʻi i nā pilikia koʻikoʻi e like me ka hyperparathyroidism lua, osteodystrophy renal, a me ka maʻi cardiovascular. ʻO ka hoʻomalu ʻana i nā pae phosphorus koko he ʻāpana koʻikoʻi o ka hoʻokele ʻana i nā maʻi CKD, a ʻo nā mea hoʻopaʻa phosphate nā lāʻau pōhaku kihi no ka mālama ʻana i ka hyperphosphatemia. I nā makahiki i hala iho nei,lanthanum carbonate, e like me ke ano hou o ka non-calcium a me ka non-aluminum phosphate binder, ua komo malie i ke kahua o ka ike kanaka a hoomaka i ka "hoʻokūkū" me kuʻuna phosphate binders.
ʻO nā "maikaʻi" a me nā "hewa" o nā mea hoʻopaʻa phosphate kuʻuna
ʻO nā mea hoʻopaʻa phosphate maʻamau ka nui o nā mea hoʻopaʻa phosphate i loko o ka calcium (e like me ka calcium carbonate a me ka calcium acetate) a me nā mea hoʻopaʻa phosphate i loko o ka alumini (e like me ka alumini hydroxide). Hoʻohui lākou me ka phosphates i loko o ka meaʻai e hana i nā pūhui insoluble, a laila e hōʻemi ana i ka absorption intestinal o ka phosphorus.
ʻO nā mea hoʻopaʻa phosphate i loko o ka calcium: ʻO ke kumu kūʻai haʻahaʻa a me ka hopena hoʻohaʻahaʻa phosphorus, akā hiki i ka hoʻohana lōʻihi ke alakaʻi i ka hypercalcemia a hoʻonui i ka pilikia o ka calcification vascular.
ʻO nā mea hoʻopaʻa phosphorus i loko o ka alumini: ʻO ka hopena hoʻohaʻahaʻa phosphorus ikaika, akā ʻo ka hoʻonui ʻana i ka alumini he mea ʻawaʻawa a hiki ke hoʻoulu i ka maʻi iwi pili i ka aluminika a me ka encephalopathy, a ʻaʻole i hoʻohana ʻia i kēia manawa.
Lanthanum carbonate: Ke piʻi aʻe nei ka mea hou, me nā pōmaikaʻi koʻikoʻi
ʻO ka lanthanum carbonate he carbonate o ka lanthanum mea metala honua, me kahi hana hoʻopaʻa phosphorus kū hoʻokahi. Hoʻokuʻu ia i nā ion lanthanum i loko o ke kaiapuni ʻakika o ka digestive tract a hana i ka lanthanum phosphate me ka phosphate, a laila e pale ai i ka absorption o ka phosphorus.
Hoʻopuka pōkole o ka lanthanum carbonate
| inoa huahana | Lanthanum carbonate |
| Kumukumu | La2(CO3)3.xH2O |
| CAS No. | 6487-39-4 |
| Kaumaha Molekala | 457.85 (anhy) |
| ʻO ka mānoanoa | 2.6 g/cm3 |
| Lae hehee | N/A |
| Ka nana aku | ʻO ka pauka aniani keʻokeʻo |
| Ka hoʻoheheʻe | Hiki ke hoʻoheheʻe ʻia i ka wai, hiki ke hoʻoheheʻe ʻia i nā ʻakika mineral ikaika |
| Paʻa | hygroscopic maʻalahi |
Ke hoʻohālikelike ʻia me nā mea hoʻopili phosphorus kuʻuna, loaʻa i ka lanthanum carbonate nā mea maikaʻi aʻe:
ʻAʻohe calcium a me aluminika, ʻoi aku ka palekana: E pale i ka pilikia o ka hypercalcemia a me ka alumini poisoning, ʻoi aku ka nui o nā maʻi me ka mālama lōʻihi a me ka pilikia o ka calcification vascular.
Hiki ke hoʻopaʻa i ka phosphorus ikaika, ka hopena hoʻemi nui o ka phosphorus: Hiki i ka Lanthanum carbonate ke hoʻopaʻa pono i ka phosphorus ma kahi ākea pH ākea, a ʻoi aku ka ikaika o kona hiki paʻa ma mua o nā mea hoʻopaʻa phosphorus kuʻuna.
ʻOi aku ka liʻiliʻi o nā hopena ʻino o ka ʻōpū, ka hoʻokō hoʻomanawanui maikaʻi: ʻono maikaʻi ʻo Lanthanum carbonate, maʻalahi ke lawe, liʻiliʻi ka ʻeha o ka ʻōpū, a ʻoi aku ka pili o nā maʻi i ka mālama lōʻihi.
Nā hōʻike noiʻi maʻi: Hana maikaʻi ka Lanthanum carbonate
Ua hōʻoia ka nui o nā noiʻi lapaʻau i ka pono a me ka palekana o ka lanthanum carbonate i nā maʻi CKD. Ua hōʻike ʻia nā haʻawina ʻaʻole ʻoi aku ka liʻiliʻi o ka lanthanum carbonate ma mua o nā mea hoʻopaʻa phosphate kuʻuna i ka hōʻemi ʻana i nā pae phosphorus koko, a hiki ke hoʻomalu pono i nā pae iPTH a hoʻomaikaʻi i nā hōʻailona metabolism iwi. Eia kekahi, ʻoi aku ka maikaʻi o ka palekana o ka mālama lōʻihi me ka lanthanum carbonate, ʻaʻole i ʻike ʻia ka hōʻiliʻili lanthanum a me nā hopena ʻawaʻawa.
Lapaʻau hoʻokahi: E koho i ka hoʻolālā maikaʻi loa no ka mea maʻi
ʻOiai he nui nā pōmaikaʻi o ka lanthanum carbonate, ʻaʻole ia he manaʻo hiki ke hoʻololi piha i nā mea hoʻopaʻa phosphate kuʻuna. Loaʻa i kēlā me kēia lāʻau nā hōʻailona a me nā contraindications, a pono e hoʻokaʻawale ʻia ka hoʻolālā lapaʻau e like me ke kūlana kūikawā o ka mea maʻi.
ʻOi aku ka maikaʻi o ka Lanthanum carbonate no nā mea maʻi:
ʻO nā maʻi me ka hypercalcemia a i ʻole ka pilikia o ka hypercalcemia
ʻO nā maʻi me ka calcification vascular a i ʻole ka pilikia o ka calcification vascular
ʻO nā maʻi me ka hoʻomanawanui maikaʻi ʻole a i ʻole ka maikaʻi ʻole o nā mea hoʻopaʻa phosphate kuʻuna
Hiki ke hoʻohana ʻia nā mea hoʻopaʻa phosphate kuʻuna no nā maʻi penei:
ʻO nā maʻi me nā kūlana hoʻokele waiwai
ʻO nā maʻi i maʻi a i ʻole ʻae ʻole i ka lanthanum carbonate
Ke nānā nei i ka wā e hiki mai ana: ʻO ka Lanthanum carbonate ka wā e hiki mai ana
Me ka hohonu o ka noiʻi lapaʻau a me ka hōʻiliʻili ʻana o ka ʻike lapaʻau, e hoʻomau ke kūlana o ka lanthanum carbonate i ka mālama ʻana i ka hyperphosphatemia i nā maʻi CKD. I ka wā e hiki mai ana, manaʻo ʻia e lilo ka lanthanum carbonate i mea hoʻopaʻa phosphate laina mua, e lawe mai ana i ka nūhou maikaʻi i nā maʻi CKD hou aʻe.
Ka manawa hoʻouna: Mar-25-2025